Blood group genotyping
Sloan, Steven R. Department of Laboratory Medicine, Children’s Hospital and Harvard Medical School - Joint Program in Transfusion Medicine, Boston, Massachusetts.
- Importance of red blood cell surface molecules (antigens)
- Traditional approach to avoiding red blood cell destruction (hemolysis)
- Traditional methods to detect red blood cell surface antigens
- Genes determine red blood cell surface molecules
- Genotyping methods
- Genotyping advantages
- Genotyping limitations
- Future directions
- Links to Primary Literature
- Additional Readings
Red blood cells express multiple molecules, including hundreds of different proteins and carbohydrates on their surfaces. These surface molecules vary among individuals. Some of these surface molecules are not present on some people's red blood cells. Other surface molecules exist in slightly different forms in different people. These variations are important during transfusion of red blood cells because cell surface molecules on the transfused red blood cells that are not present on a patient's red blood cells are “foreign” and can induce an immune response in the patient.
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