Biomarkers: key to exposure reconstruction
Tan, Yumei National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina.
Phillips, Martin National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina.
Sobus, Jon National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina.
Chang, Daniel T. National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina.
Goldsmith, Michael R. National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina.
Last reviewed:October 2021
Show previous versions
- Biomarkers: key to exposure reconstruction, published December 2014:Download PDF Get Adobe Acrobat Reader
- Exposure reconstruction
- Biomarkers of exposure
- Incorporating biomarkers in exposure reconstruction
- Forward predictions
- Reverse predictions
- Examples of computational models
- Related Primary Literature
- Additional Reading
Identifying exposure sources, routes, frequency, duration, and magnitude using biomarker data combined with other approaches, such as computational models and available environmental measurement data. The goal of environmental health science is to understand the interplay between the environment and humans to evaluate the effects of human activities on the public health and environment and, conversely, to evaluate the effects of various aspects of the environment on human health. When investigating the effects that exposures to chemicals have on human health, the major challenge lies in establishing the causal relationship between the magnitude of exposure to these chemicals and the incidence of adverse outcomes (such as cancer and irritation) at various biological endpoints. This causal relationship can be established only when all elements on the source–exposure–dose–effect continuum are linked (Fig. 1).
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 10,000 highly qualified scientists and 46 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information