- Biology & Biomedicine
- Biochemistry and molecular biology
- Biological relevance of metal complexes of nitric oxide
Biological relevance of metal complexes of nitric oxide
Boon, Elizabeth M. Department of Chemistry, Stony Brook University, Stony Brook, New York.
Muralidharan, Sandhya Department of Chemistry, Stony Brook University, Stony Brook, New York.
- Nitric oxide synthesis
- NO is a potent toxin
- NO is a powerful signaling molecule in eukaryotes
- Evidence for NO signaling in bacteria
- Links to Primary Literature
- Additional Readings
Nitric oxide (NO) is a diffusible free-radical gas. It has well-characterized reactivity with molecules such as molecular oxygen (O2), metal ions, and thiols, but the physiological function of NO is intimately linked to its in vivo concentration. At high concentrations, NO is a potent toxin used to kill invading pathogens and tumor cells by indiscriminately reacting with cellular components. At relatively low concentrations (≤ micromolar), NO typically reacts with the metal centers (usually iron) of specific metalloproteins, where it mediates cellular response to nitrosative stress. At very low concentrations (≤ nanomolar), NO functions as a signaling molecule that regulates many physiological functions such as vasodilation and neurotransmission through its interaction with a selective, sensitive, and reversible sensor.
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