Weinstein, Brant M. National Institute of Child Health and Human Services, Bethesda, Maryland.
Last reviewed:January 2018
Show previous versions
- Blood vessel formation
- Molecular regulators
- Clinical importance
- Antiangiogenic therapy
- Proangiogenic therapy
- Animal developmental models
- Links to Primary Literature
- Additional Readings
The origin and development of blood vessels. Angiogenesis is the process through which new blood vessels are formed. Blood vessels (Fig. 1) are composed of two basic cell types: vascular endothelial cells and periendothelial cells (including vascular smooth muscle cells and elongated contractile cells called pericytes, both of which support the underlying endothelial cells). The inner epithelial lining of all blood vessels, adjacent to the lumen, is a single layer of endothelial cells. In larger blood vessels, such as arteries and veins, the inner endothelial lining, called the tunica intima (Fig. 2), is surrounded by a medial layer, the tunica media, composed of multiple layers of vascular smooth muscle cells embedded in an elastin-rich extracellular matrix. The tunica media layer is surrounded by an extracellular matrix–rich layer called the tunica adventitia (also referred to as the tunica externa) [Fig. 2]. In contrast, capillary walls consist of only a single layer of endothelial cells, sometimes surrounded by pericytes. See also: Blood; Blood vessel; Elastin; Vascular development
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8500 articles and Research Reviews covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information