Alternative RNA splicing
Convertini, Paolo Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky.
Stamm, Stefan Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky.
- Definition of alternative pre-mRNA splicing
- Splice site selection
- Alternative exon plasticity
- Function of alternative splicing
- Alternative splicing is connected to other parts of gene expression
- Splicing and disease
- Conclusions and perspectives
- Links to Primary Literature
- Additional Readings
To convert the genetic information stored in deoxyribonucleic acid (DNA) to proteins, the DNA is transcribed to produce an intermediate called precursor messenger ribonucleic acid (pre-mRNA). Only parts of the pre-mRNA, the exons (which comprise less than 5% of the average human gene), are exported into the cytosol as mature mRNA. Prior to the formation of mRNA, the exons are spliced together, which removes intermediate (intronic) sequences. Notably, this process can be alternative, which allows an organism to determine which parts of the DNA are translated into proteins (Fig. 1). Alternative splicing affects more than 92% of human genes, making it one of the most versatile mechanisms to increase the use of genetic information stored in DNA.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Its dedicated editorial team is led by Sagan Award winner John Rennie. Contributors include more than 9000 highly qualified scientists and 42 Nobel Prize winners.
MORE THAN 8500 articles and Research Reviews covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 17,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information