Lipid rafts (membranes)
Fielding, Christopher J. Cardiovascular Research Institute, University of California Medical Center, San Francisco, California.
- Caveolae and lipid raft morphology
- Presence in cells
- Targeted protein assembly
- Signal transduction
- Caveolae, rafts, and cellular FC homeostasis
- Lipid rafts and viral infectivity
- Links to Primary Literature
- Additional Readings
Microdomains of the cell surface that play key roles in promoting information transfer across the membrane bilayer. The plasma membrane is composed of a lipid bilayer into which are inserted various essential proteins, such as transmembrane ion-channel and transporter proteins (which allow for the movement of small molecules into and out of the cell) and signaling proteins. Many of these proteins are found associated with domains on the surface of the membrane which are rich in free cholesterol (FC) and sphingolipids (lipids containing the amino acid sphingosine or its derivatives); some lipid components of transmembrane signaling pathways are also found here. It seems likely that both leaflets of the bilayer contribute to the structure of the microdomains. It is now evident that these rafts consist of a mixture of two quite different types of FC- and sphingolipid-rich domains: bowl-shaped caveolae and flat lipid rafts. Both caveolae and lipid rafts act as assembly sites (scaffolds) for signaling complexes, and may have important roles in signal transduction and other crucial intracellular functions. See also: Cell membranes
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