Schizophrenia risk genes
Zhang, Zhengdong D. Department of Genetics, Albert Einstein College of Medicine, Bronx, New York.
Last reviewed:August 2017
- Schizophrenia risk genes in neurotransmitter systems
- Schizophrenia risk genes identified by genetic studies
- Related Primary Literature
- Additional Reading
Sequences of deoxyribonucleic acid (DNA) that increase the probability of the development of schizophrenia in an individual. Schizophrenia risk genes increase the likelihood of developing schizophrenia, a debilitating brain disorder characterized by constellations of symptoms such as hallucinations, delusions, and cognitive impairments. Most cases of schizophrenia start during adolescence or early adulthood and often have a lifelong course. With substantial morbidity and mortality and a worldwide prevalence of approximately 1%, schizophrenia creates an enormous burden to patients, their families, and the community. Converging evidence indicates that schizophrenia results from a disruption in brain development caused by genetic predisposition and environmental factors (for example, prenatal infection, maternal nutrition, and stress). It is a highly heritable disease, with an estimated heritability between 64% and 81%, confirming the major role of genetic factors in contributing to disease risk. Accumulating evidence indicates that schizophrenia is associated with many genes and involves complex interactions among risk variants (see illustration) across a wide range of the frequency spectrum of alleles (alternative gene forms). Overall, the identification of schizophrenia risk genes is crucial for providing insight into the underlying disease mechanisms and for determining new drug targets. See also: Brain; Cognition; Gene; Genetics; Genomics; Hallucination; Mental disorders; Psychotherapy; Schizophrenia; Schizophrenia and prenatal infection
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information