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An interdisciplinary field in which the principles, laws, and techniques of engineering, physics, chemistry, and other physical sciences are applied...
Tissue engineering involves the use of biomaterials, transplanted cell populations, and molecular signals in the regeneration of diseased or damaged...
There is a great shortage of organs for transplantation, generating a need for alternative treatments for organ loss. Induced organ regeneration is...
The loss or failure of an organ is one of the most devastating and costly problems in health care. The current options for treatment include...
Tissue and organ transplantation has saved countless lives and significantly changed medical practice. New technologies aim to improve clinical...



= Encyclopedia Article; = Research Update
Comparison of (a) normal and (b) regenerated skin. The dermal-epidermal junction of regenerated skin shows capillary loops inside the rete ridges. Neither rete ridges nor capillary loops form in scar. Presence of rete ridges is one of two major features that distinguish intact and regenerated skin from scar. Another distinguishing feature is presence of quasirandomly oriented collagen fibers in the intact and regenerated dermis, rather than a highly aligned stroma, as in dermal scar. (C. C. Compton et al., Organized skin structure is regenerated in vivo from collagen-GAG matrices seeded with autologous keratinocytes, J. Invest. Dermatol.,110:908–916, 1998)
From update 'Organ regeneration'
Figure 1.Configurations of implantable closed-system devices for cell transplantation. (After R. Langer and J. P. Vacanti, Tissue engineering, Science, 260:920–926, 1993; copyright 1996 by the American Association for the Advancement of Science)
From update 'Tissue engineering'
Figure 1.Examples of commonly used polymers in tissue engineering: (a) poly(a-hydroxy esters), (b) poly-(anhydrides), (c) poly(ethylene glycol), and (d) poly-(phosphoesters).
From update 'Tissue engineering'