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Search Results: Biomechanical measurement in cells

The field of biomechanics has undergone revolutionary changes in recent years. Early developments in the field focused mainly on phenomena at the...


= Encyclopedia Article; = Research Update
Figure 1.Principle of traction force microscopy. Cells are placed on a deformable substrate (for example, silicone rubber or polyacrylamide gel) coated with extracellular matrix proteins, usually with microbeads embedded under the surface for visualizing deformation. As cells actively contract or migrate along the surface, displacement of the beads is observed. Based on known elastic properties of the substrate, computational algorithms have been developed to convert bead displacements into traction forces or stresses.
Figure 2.Post-array detector device with extracellular matrix proteins coated on top of the posts. The deflection of each post is proportional to the traction force exerted on the post by the cell.
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