Amino acid metabolism

Article By:

Stipanuk, Martha H. Division of Nutritional Sciences, Cornell University, Ithaca, New York.

Last updated:2014

DOI:https://doi.org/10.1036/1097-8542.550300

The sum of the biochemical and physiological processes involved in the generation and degradation of amino acids, particularly those utilized as substrates for protein biosynthesis. Via amino acid metabolism, 20 α-amino (or α-imino, in the case of proline), α-carboxylic acids are precursors or building blocks for synthesis of proteins and peptides in the body. Proteins consist of linear polymers of amino acids, and they are synthesized by formation of peptide bonds between the α-carboxyl and α-amino groups of adjacent amino acids. Proteins make up approximately 17% of the body mass [about 12 kg (26.4 lb) in a 70-kg (154-lb) adult]. Amino acids also are necessary substrates for the synthesis of numerous nonprotein nitrogenous molecules such as nucleotides, creatine, heme, folate polyglutamates, epinephrine, and serotonin. In addition, they play important roles in the transport of nitrogen between organs. When amino acids are available in surplus of what is consumed for these synthetic processes, they are catabolized to carbon compounds that are then either oxidized directly or used to synthesize glucose or triglycerides for storage or oxidation as fuels. See also: Amino acids; Metabolism; Peptide; Protein

The content above is only an excerpt.